刘璞钰，严 青，肖业玺琳，刘 洋，王天翔，赵保堂^*

（甘肃农业大学食品科学与工程学院，甘肃兰州 730070）

摘要：多糖是由多个单糖分子缩合而成的一类重要的大分子物质，因其具有抗病毒、抗癌、抗氧化、调节免疫、降血糖等生物活性，受到广泛关注，通过多糖的结构修饰（如硫酸化、羧甲基化、磷酸化等）可提高其生物活性，甚至产生新的生物活性。文章就多糖磷酸化修饰方法、多糖磷酸酯结构表征、生物活性等方面进行概述，以期为多糖磷酸化修饰提供参考依据。

关键词：磷酸化多糖；结构分析；生物活性

中图分类号：Q53   文献标识码：A   文章编号：1674-506X（2021）01-0102-0005

Research Progress of Phosphorylation Modification of Polysaccharides

LIU Pu-yu, YAN Qing, XIAO Ye-xilin, LIU Yang, WANG Tian-xiang, ZHAO Bao-tang^*

（College of Food Science and Engineering, Gansu Agricultural University, Lanzhou Gansu 730070, China）

Abstract：Polysaccharides which consisted by many monosaccharides is an important macromolecular. It has a variety of biological activities, such as anti-virus, anti-tumor, anti-oxidation, immune regulation and hypoglycemic effect. Therefore, researchers pay more attention on polysaccharides. Biological activities of polysaccharides can be improved by structural modification (such as sulfation, carboxymethylation, phosphorylation, et al.) and even produce new biological activities. The methods of phosphorylation and characteristic and biological activities of phosphorylated polysaccharides are summarized in order to provide some reference for further research.

Keywords：phosphorylated polysaccharides; structural analysis; biological activity

doi：10.3969/j.issn.1674-506X.2021.01-019

收稿日期：2020-06-21

基金项目：甘肃农业大学大学生科研训练计划项目（202009056）

作者简介：刘璞钰（1999-），女，本科。

*通信作者

引文格式：刘璞钰,严青,肖业玺琳,等.多糖磷酸化修饰的研究进展[J].食品与发酵科技,2021,57(1):102-106.